Hyperhomocysteinemia: Relation to Cardiovascular Disease and Venous Thromboembolism
نویسندگان
چکیده
Homocysteine is a sulphur-containing amino acid, which structurally is closely related to the essential amino acids methionine and cysteine. The cellular methylation cycle performs the metabolism of methionine and since homocysteine is an intermediate within this cycle, the body in this way is provided with all organic homocysteine. The term homocysteine is used to define the combined pool of homocysteine, homocystine, and mixed disulfide compounds (Fig. 1) even involving homocysteine thiolactone a cyclic form which is often found in the plasma of patients with hyperhomocisteinemia.
منابع مشابه
[Hyperhomocysteinemia as a risk factor for cardiovascular disease].
Cardiovascular and peripheral vascular disease are the major cause of morbidity and mortality in general population today. Hyperhomocysteinemia, a new independent risk factor for atherosclerotic vascular disease, has been described in the last ten years. Moderate hyperhomocysteinemia occurs in 5-7% of general population, and is associated in the third and fourth deceny of life with premature co...
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In the last couple of decades many studies have been carried out on the association of moderately high plasma levels of total homocysteine (tHcy) with coronary artery disease, cerebrovascular disease, peripheral artery disease and venous thromboembolism. Most studies showed a positive association between tHcy and thrombosis risk. However, despite this, many investigators are still skeptical abo...
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Hyperhomocysteinemia is associated with ischemic cardiovascular disease (ICD) and venous thromboembolism (VTE). We tested the hypothesis that methylenetetrahydrofolate reductase (MTHFR) C677T homozygosity with hyperhomocysteinemia is associated with ICD and VTE. First, 9238 randomly selected whites from the general population were followed for 23 years. Second, 2125 whites with ischemic heart d...
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Background and Objective: Venous thromboembolism is one of the major causes of mortality worldwide. Various environmental and genetic factors are known as risk factors for this disease. Therefore, this study aimed to investigate the frequency of risk factors in patients with venous thromboembolism admitted to Ekbatan and Farshchian hospitals in Hamadan from 2012 to 2017. Materials and Methods:...
متن کاملHomocysteine and cardiovascular disease.
An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism. The basis for these conclusions is data from about 80 clinical and epidemiological studies including more than 10,000 patients....
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